Skip to main content
BuilderBrew.com
JobsInvestorsCompaniesStatsAboutFAQ
BuilderBrew

Insights for software builders, engineers, and growth operators.

Browse jobs

  • All jobs
  • Categories
  • Skills
  • States
  • Cities
  • Counties
  • Experience
  • Location type
  • Employment type
  • Salary
  • Funding
  • Company size
  • Total funding
  • Funded within

Explore

  • About
  • FAQ
  • Companies
  • Investors
  • Stats

Company

  • Terms of Service
  • Privacy Policy

© 2026 BuilderBrew.com. All rights reserved.

Join a startup on the way up — not a bet, not a giant.

Tech roles at Series A–C companies backed by Sequoia, a16z, Benchmark & other top-tier VCs

  • Sequoia
  • a16z
  • Benchmark
  • Accel
  • Greylock
  • Founders Fund
  • General Catalyst
  • Index Ventures
  • Lightspeed
  • Bessemer
  • Coatue
  • Insight Partners
  • IVP
  • NEA
  • Thrive Capital
  • Sequoia
  • a16z
  • Benchmark
  • Accel
  • Greylock
  • Founders Fund
  • General Catalyst
  • Index Ventures
  • Lightspeed
  • Bessemer
  • Coatue
  • Insight Partners
  • IVP
  • NEA
  • Thrive Capital

Open roles

High-signal tech roles at Series A–C companies, refreshed as boards update.

20 results on this page
Jobs per page
PreviousPage 24Next
PlanetScale logo
Developer Educator
1/20Posted 2 weeks ago

PlanetScale · San Luis, Yuma County, Arizona

$130,000 - $200,000
Remote
20 results on this page
Jobs per page
PreviousPage 24Next
Series C
Funded Nov 2021
51–200
$100M-$1B
Andreessen Horowitz (a16z)
Insight Partners
Distributed Systems
MySQL
PostgreSQL
Vitess
Posted 2 weeks agoSee job

PlanetScale is seeking a Developer Educator to create technical content, speak at conferences, and build the developer community. The role involves teaching about Postgres, MySQL, Vitess, and the PlanetScale ecosystem, with 20-50% travel.

PlanetScale logo
Software Engineer - Sharded Postgres (Neki)
2/20Posted 2 weeks ago

PlanetScale · Bay Area, San Francisco County, California

$120,000 - $290,000
Remote
Series C
Funded Nov 2021
51–200
$100M-$1B
Andreessen Horowitz (a16z)
Insight Partners
Amazon Web Services (AWS)
C++
Distributed Systems
Go
+6 more
Posted 2 weeks agoSee job

PlanetScale is looking for a Software Engineer to help build Neki, a sharded PostgreSQL product. The role involves designing critical database infrastructure, solving distributed systems challenges, and working with customers. Requires 5+ years of backend experience and strong Go proficiency.

PlanetScale logo
Software Engineer - Neki Orchestration
3/20Posted 2 weeks ago

PlanetScale · San Francisco, San Francisco County, California

$120,000 - $290,000
Remote
Series C
Funded Nov 2021
51–200
$100M-$1B
Andreessen Horowitz (a16z)
Insight Partners
Amazon Web Services (AWS)
Data Storage
Distributed Systems
Go
+12 more
Posted 2 weeks agoSee job

PlanetScale is seeking a Software Engineer to build the control plane for Neki, its sharded PostgreSQL product. The role involves designing orchestration, high availability, and automation for database operations, and requires 5+ years of experience with Go, Kubernetes, and distributed systems.

PlanetScale logo
Software Engineer - PlanetScale Postgres
4/20Posted 2 weeks ago

PlanetScale · Myrtle Point, Coos County, Oregon

$120,000 - $290,000
Remote
Series C
Funded Nov 2021
51–200
$100M-$1B
Andreessen Horowitz (a16z)
Insight Partners
Amazon Web Services (AWS)
Distributed Systems
Go
Google Cloud Platform (GCP)
+7 more
Posted 2 weeks agoSee job

PlanetScale is seeking a Software Engineer to build a world-class managed Postgres offering. The role involves designing the control plane, ensuring high availability, and tuning Postgres at scale. Requires 5+ years of experience, strong Go skills, and distributed systems expertise.

Profluent Bio logo
Scientist II, mRNA Research & Production
5/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$147,000 - $161,000
Onsite
Series B
11–50
$100M-$1B
Insight Partners
Posted 2 weeks agoSee job

Profluent is seeking a Scientist II to drive mRNA production and process development for customized base editor programs. This hands-on lab role involves synthesis, purification, characterization, and optimization of research-grade mRNA for high-throughput screening and scaled production for mouse studies.

Daily job alert

Get new VC-backed tech jobs in your inbox every morning.

Narrow your alert

Free daily email. Confirm via link to activate. Unsubscribe anytime.

Profluent Bio logo
Associate Director - Director, In Vivo Pharmacology
6/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$200,000 - $260,000
Onsite
Series B
11–50
$100M-$1B
Insight Partners
Clinical Chemistry
Computational Biology
Immunology
Posted 2 weeks agoSee job

Profluent is seeking an Associate Director/Director to lead in vivo pharmacology strategy for base editor therapeutics, overseeing rodent and NHP studies from discovery to IND-enabling. The role involves cross-functional leadership, CRO management, and building scalable pharmacology capabilities.

Profluent Bio logo
Senior Software Engineer, Data Platform
7/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$170,000 - $220,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
BigQuery
CI/CD
Git
Google Cloud Platform (GCP)
+4 more
Posted 2 weeks agoSee job

Profluent is seeking a Senior Software Engineer to design, build, and scale its data platform for protein engineering campaigns. The role involves building secure pipelines, data warehouses, and infrastructure using Python, GCP, BigQuery, and PostgreSQL to enable machine learning and biological discovery.

Profluent Bio logo
Biotech Project Manager, Early Discovery
8/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$115,000 - $150,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Bioinformatics
Generative AI
Jira
Smartsheet
Posted 2 weeks agoSee job

Profluent, a frontier AI lab for biology, seeks a Biotech Project Manager to orchestrate internal and external programs, building comprehensive timelines across bioinformatics, ML, and wet-lab validation. The role requires 3-5 years of project management experience in biotech, with strong skills in Jira and SmartSheet.

Profluent Bio logo
Software Engineering Manager, Lab Informatics Platform
9/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$180,000 - $250,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
APIs
CI/CD
Python
Posted 2 weeks agoSee job

Profluent is seeking a product-minded engineering manager to lead its Lab Informatics Platform team, overseeing software development for scientific data infrastructure, sample tracking, and Benchling integration. The role involves mentoring engineers, architecting systems, and partnering with scientists to accelerate experimental workflows.

Profluent Bio logo
Machine Learning Scientist, BioML
10/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$200,000 - $330,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Amazon Web Services (AWS)
Google Cloud Platform (GCP)
JAX
Microsoft Azure
+2 more
Posted 2 weeks agoSee job

Profluent, an AI lab for biology, seeks a Machine Learning Scientist to drive research on generative models for protein design. The role involves developing state-of-the-art models, collaborating with interdisciplinary teams, and shaping ML strategy. Requires PhD and experience in ML and biology.

Daily job alert

Get new VC-backed tech jobs in your inbox every morning.

Narrow your alert

Free daily email. Confirm via link to activate. Unsubscribe anytime.

Profluent Bio logo
Executive Director / Vice President, Biology & Translational Pharmacology
11/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$270,000 - $340,000
Onsite
Series B
11–50
$100M-$1B
Insight Partners
Artificial Intelligence
Computational Biology
Foundation Models
RNA Interference (RNAi)
Posted 2 weeks agoSee job

Profluent is seeking an Executive Director / VP of Biology & Translational Pharmacology to lead scientific strategy and execution of gene editing therapeutic programs, focusing on liver-directed base editing for metabolic diseases.

Profluent Bio logo
Machine Learning Scientist, Reinforcement Learning
12/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$200,000 - $330,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Amazon Web Services (AWS)
Bioinformatics
Deep Learning
Foundation Models
+7 more
Posted 2 weeks agoSee job

Profluent, an AI lab for biology, seeks a Machine Learning Scientist to drive research into reinforcement learning for biomolecular design. The role involves developing state-of-the-art RL algorithms for protein design, collaborating with cross-functional teams, and shaping the ML direction as an early employee.

Profluent Bio logo
Scientist II - Sr. Scientist, CRISPR Specificity & Genomic Safety
13/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$147,000 - $177,000
Onsite
Series B
11–50
$100M-$1B
Insight Partners
Bioinformatics
Genomics
Machine Learning
Posted 2 weeks agoSee job

Profluent is seeking a Scientist II - Sr. Scientist to build and apply experimental workflows for characterizing CRISPR base editing specificity and genomic safety. The role involves developing assays like CHANGE-seq-BE, interpreting NGS data, and collaborating with cross-functional teams to guide editor design and therapeutic development.

Profluent Bio logo
Controller
14/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$185,000 - $230,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Coupa
NetSuite
SOC 2 Compliance
Posted 2 weeks agoSee job

Profluent, a frontier AI lab for biology, is seeking a Controller to lead its accounting function, including financial close, technical accounting, equity, treasury, and compliance, as the company scales toward a public-company environment.

Profluent Bio logo
Lead Bioinformatics Scientist, NGS
15/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$160,000 - $230,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Amazon Web Services (AWS)
Bioinformatics
CI/CD
Computational Biology
+11 more
Posted 2 weeks agoSee job

Profluent seeks an experienced computational scientist to lead the design and development of NGS analysis pipelines for gene editing and protein design, working at the intersection of computational biology and software engineering.

Daily job alert

Get new VC-backed tech jobs in your inbox every morning.

Narrow your alert

Free daily email. Confirm via link to activate. Unsubscribe anytime.

Profluent Bio logo
Machine Learning Scientist, Pretraining
16/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$200,000 - $330,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Amazon Web Services (AWS)
Bioinformatics
Deep Learning
Google Cloud Platform (GCP)
+6 more
Posted 2 weeks agoSee job

Profluent, an AI lab for biology, seeks a Machine Learning Scientist to drive research into pretraining large-scale deep learning models for biomolecular design. The role involves developing state-of-the-art generative models, collaborating with interdisciplinary teams, and shaping ML strategy.

Profluent Bio logo
Machine Learning Research Engineer
17/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$200,000 - $330,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Amazon Web Services (AWS)
CUDA
Docker
Google Cloud Platform (GCP)
+6 more
Posted 2 weeks agoSee job

Profluent, an AI lab for biology, seeks an experienced Machine Learning Engineer to build and improve models and ML systems for protein design, including large-scale generative models, pipelines, and infrastructure.

Profluent Bio logo
Scientist II, ML - Guided Protein Design Evaluation
18/20Posted 2 weeks ago

Profluent Bio · Emeryville, Alameda County, California

$147,000 - $180,000
Hybrid
Series B
11–50
$100M-$1B
Insight Partners
Foundation Models
Laboratory Information Management System (LIMS)
Machine Learning
Pandas
+2 more
Posted 2 weeks agoSee job

Profluent, a frontier AI lab for biology, seeks a Scientist II to lead the ML Design Evaluation program, bridging ML and experimental biology to generate high-quality data for protein design models. The role involves scoping assays, defining QC standards, and collaborating with ML and protein design teams.

Whop logo
Engineering
19/20Posted 2 weeks ago

Whop · Palo Alto, Santa Clara County, California

Onsite
Series B
51–200
$100M-$1B
Insight Partners
Posted 2 weeks agoSee job

Whop is hiring engineers of three types: hardcore, design, and business-savvy. They focus on simplicity, user delight, and business impact. The mission is to deliver everyone a sustainable income.

Whop logo
U.S. Indirect Tax Senior Manager
20/20Posted 2 weeks ago

Whop · Palo Alto, Santa Clara County, California

$150,000 - $225,000
Hybrid
Series B
51–200
$100M-$1B
Insight Partners
Posted 2 weeks agoSee job

Whop is seeking a Senior Manager, U.S. Indirect Tax to lead sales and use tax strategy, compliance, audits, and tax operations for its internet commerce platform. This hybrid role in Palo Alto requires 15+ years of indirect tax experience and deep expertise in digital product taxation and marketplace facilitator laws.

Daily job alert

Get new VC-backed tech jobs in your inbox every morning.

Narrow your alert

Free daily email. Confirm via link to activate. Unsubscribe anytime.